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Investigation of the role of the vascular endothelium and the possible factors involved in early endothelial dysfunction and its modification in normal children and adults, and in asymptomatic disease, as well as in established vascular disease states. Novel non-invasive techniques for transdermal drug delivery (iontophoresis) and microvascular blood flow assessment (laser Doppler imaging) are been used. These assessments are being complemented by measurement of arterial endothelial function and arterial compliance, using high-resolution ultrasound and arterial waveform analysis. Potentially, the most exciting future direction relates to detection and improvement of endothelial function in children and young adults through modification in diet and lifestyle.
Khan F, Elherik K, Bolton-Smith C, Barr R, Hill A, Murrie I, Belch JJF. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovascular Research 2003; 59: 955-962.
Khan F, Green FC, Forsyth JS, Greene SA, Morris AD, Belch JJF. Impaired microvascular function in normal children: effects of adiposity and poor glucose handling. Journal of Physiology 2003; 551.2: 705-711.
Khan F, Mires G, McLeod M, Belch JJF. Changes in endothelial function precede the clinical disease in women who develop pre-eclampsia. Hypertension 2005; 46: 1123-1128.
Belch JJF, Anderson AS, Greene SA, Khan F, Greene AC. (2004 - 2006) Changing lifestyle in children: can this reduce cardiovascular risk? (Scottish Executive).
Belch JJF, Anderson AS, Khan F, McLaren M, Ibbotson S, Davies H, Stewart D, Brennan R. (2005 - 2007) Cardiovascular function and berry intake: effect of variation in anti-oxidant intake (Chest, Heart & Stroke, Scotland).
Galarraga B, Belch JJF, Pullar T, Khan F, Hill A (2005 - 2007) Effect of etanercept on endothelial dysfunction and other surrogate markers of cardiovascular disease in patients with rheumatoid arthritis (Wyeth pharmaceuticals)